Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 30044생성일: 2026년 10월 23일
Sodium Hydroxide → 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine
https://huagongshe.com/ko/reaction/30044
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine | HCID 11554683 | — |
| 반응물 | Pyridinium hydrochloride | HCID 21584435 | — |
| 생성물 | 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine | HCID 136394903 | 86.8% |
반응 단계
A mixture of 597 mg (1.25 mmol) of 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine (compound 1) and pyridinium hydrochloride is heated at 210° C. for 45 minutes. The reaction medium is cooled and 1N sodium hydroxide solution is then added. A precipitate forms, which is washed with water and with dichloromethane, and then dried under reduced pressure. 500 mg of a beige-coloured powder are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07423030B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-e9b7e2235a7a47bfab84ebdfc02c564b |
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| 출처 메모 | uspto-grants-2008_09 |
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