2-Naphthalenecarboxaldehyde → (3S)-1-(Naphthalen-2-ylmethyl)-3-tert-butyloxycarbonylamino-pyrrolidine

HRID 30066

반응식

HRID 30066 반응식
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[CH:24]=O>>[CH:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16][C:15]=1[CH2:24][N:11]1[CH2:12][CH2:13][C@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:10]1

참가 물질

3

반응물 2

HCID 62012-NaphthalenecarboxaldehydeHCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine

생성물 1

HCID 69213934(3S)-1-(Naphthalen-2-ylmethyl)-3-tert-butyloxycarbonylamino-pyrrolidine

실험 절차

This compound was obtained via the reductive amination method described in 49.2, by reaction of (S)-3-tert-butyloxycarbonylaminopyrrolidine with 2-naphthaldehyde. The residue is purified on a column of silica (eluent: from 100/0 to 90/10 (v/v) dichloromethane/methanol).

후처리

  1. customThis compound was obtained via the reductive amination method
  2. customThe residue is purified on a column of silica (eluent: from 100/0 to 90/10 (v/v) dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-dadb7808e29e48798b1fe63f2e673fc1
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423030B2

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