Sodium Carbonate → (+/-)-1-(Oxiranylmethyl)-2,4-imidazolidinedione

HRID 30091

반응식

HRID 30091 반응식
[CH2:1]([N:4]1[CH2:8][C:7](=[O:9])[NH:6][C:5]1=[O:10])[CH:2]=[CH2:3].ClC1C=C(C(OO)=[O:19])C=CC=1.S(=O)(O)[O-].C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[O:19]1[CH2:3][CH:2]1[CH2:1][N:4]1[CH2:8][C:7](=[O:9])[NH:6][C:5]1=[O:10]

참가 물질

6

반응물 4

HCID 10340Sodium CarbonateHCID 70297m-Chloroperbenzoic acidHCID 104748BisulfiteHCID 220209241-(Prop-2-en-1-yl)imidazolidine-2,4-dione

생성물 1

HCID 22020929(+/-)-1-(Oxiranylmethyl)-2,4-imidazolidinedione수율 89%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A reaction solution of 1-(2-propenyl)-2,4-imidazolidinedione (0.036 mol) and 3-chloro-benzenecarboperoxoic acid (0.043 mol, 70.75%) in DCM (25 ml) was stirred for 2 hours at room temperature. An aqueous solution of bisulfite was added and the mixture was stirred for 10 minutes. Na2CO3 was added and this mixture was extracted with DCM. The separated organic layer was dried, filtered and the solvent evaporated, yielding 5 g of (±)-1-(oxiranylmethyl)-2,4-imidazolidinedione (intermediate 18).

후처리

  1. extractionthis mixture was extracted with DCM
  2. customThe separated organic layer was dried
  3. filtrationfiltered
  4. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-2d6311f3fe124212b3572c7a948ab5ac
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423048B2

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