2-Bromo-4-fluoroanisole → (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-phenyl)-methanone

HRID 30117

반응식

HRID 30117 반응식
[NH2:1][C:2]1[N:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].Br[C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[O:23][CH3:24]>>[NH2:1][C:2]1[C:3]([C:4]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[O:23][CH3:24])=[O:5])=[CH:10][CH:11]=[C:12]([Cl:14])[N:13]=1

참가 물질

3

반응물 2

HCID 1362922-Bromo-4-fluoroanisoleHCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

생성물 1

HCID 58590829(2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-phenyl)-methanone

실험 절차

The title compound was prepared from 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide (Example 3) and 2-bromo-4-fluoroanisole (Aldrich) using the procedure described in Example 7. HRMS, observed: 280.0417, Calcd for M+: 280.0415.

출처 및 근거

ORD 기록
ord-139c7582a2184a3e8bb025b5d221774a
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423051B2

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