Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propanesulfonyl chloride → {2-Amino-6-[1-(propane-2-sulfonyl)-piperidin-4-ylamino]-pyridin-3-yl}-(5-fluoro-2-methoxy-phenyl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propanesulfonyl chloride | HCID 82408 | — |
| 반응물 | [4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 21070627 | — |
| 생성물 | {2-Amino-6-[1-(propane-2-sulfonyl)-piperidin-4-ylamino]-pyridin-3-yl}-(5-fluoro-2-methoxy-phenyl)-methanone | HCID 11561482 | — |
반응 단계
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and isopropyl sulfonyl chloride (Aldrich 97%) using the procedure described in Example 24. HRMS, observed: 451.1814, Calcd for (M+H)+: 451.1810.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423051B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a3e226a410c248d2a8aaa06ac3cfb5b0 |
| 출처 메모 | uspto-grants-2008_09 |