반응식
F[C:2](F)(F)[C:3]([OH:5])=O.[NH2:8][C:9]1[C:14]([C:15]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[O:16])=[CH:13]N=[C:11]([NH:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:10]=1.[C:33](Cl)(=O)C>>[NH2:8][C:9]1[N:10]=[C:11]([NH:26][CH:27]2[CH2:32][CH2:31][N:30]([C:3](=[O:5])[CH3:2])[CH2:29][CH2:28]2)[CH:33]=[CH:13][C:14]=1[C:15](=[O:16])[C:17]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=1[O:24][CH3:25]참가 물질
3
실험 절차
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and acetyl chloride (Aldrich 98.5%) using the procedure described in Example 24. HRMS, observed: 387.1833, Calcd for (M+H)+: 387.1827.
출처 및 근거
- ORD 기록
- ord-9a1d573ea0bf4a6aa58bc6cbb1b37522
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07423051B2
연결된 노트
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