Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propionyl chloride → 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-propan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propionyl chloride | HCID 62324 | — |
| 반응물 | [4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 21070627 | — |
| 생성물 | 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-propan-1-one | HCID 11596467 | — |
반응 단계
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and propionyl chloride (Aldrich 98%) using the procedure described in Example 24. HRMS, observed: 401.1988, Calcd for (M+H)+: 401.1984.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423051B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-51a8141126be4a24955fdb8816211cb2 |
| 출처 메모 | uspto-grants-2008_09 |