4-Fluoroiodobenzene → (2-Amino-6-chloro-pyridin-3-yl)-(4-fluoro-phenyl)-methanone

HRID 30134

반응식

HRID 30134 반응식
[NH2:1][C:2]1[N:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[F:15][C:16]1[CH:21]=[CH:20][C:19](I)=[CH:18][CH:17]=1>>[NH2:1][C:2]1[C:3]([C:4]([C:19]2[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=2)=[O:5])=[CH:10][CH:11]=[C:12]([Cl:14])[N:13]=1

참가 물질

3

반응물 2

HCID 96054-FluoroiodobenzeneHCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

생성물 1

HCID 58590828(2-Amino-6-chloro-pyridin-3-yl)-(4-fluoro-phenyl)-methanone

실험 절차

The title compound was prepared from 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide (Example 3) and 1-fluoro-4-iodobenzene (Aldrich 99%) using the procedure described in Example 7. HRMS, observed: 250.0314, Calcd for M+: 250.0309.

출처 및 근거

ORD 기록
ord-63e9c089843b45879c1458c9f2b44eb9
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423051B2

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