3-Fluoroacetophenone → 3-Fluorophenacyl bromide

HRID 30153

반응식

HRID 30153 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Br:11]Br>O1CCOCC1>[Br:11][CH2:9][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)=[O:10]

참가 물질

4

반응물 2

HCID 99673-FluoroacetophenoneHCID 24408Bromine

생성물 1

HCID 27374513-Fluorophenacyl bromide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of 1-(3-fluorophenyl)ethanone (14.0 g, 100 mmol) (Aldrich) in dioxane (250 mL) at 12-15° C. was treated with a solution of bromine (17 g, 105 mmol) in dioxane (120 mL) drop wise over 0.5 h. This was stirred for 15 min and most of the solvent removed. The residue was taken up in hexane (200 mL), washed 2× water, and dried (MgSO4). Solvent was removed to give 2-bromo-1-(3-fluorophenyl)ethanone. 1H NMR (CDCl3), 300 MHz) δ3.71 (s, 2H, CH2), 7.30-7.77(m, 4H, Aromatic).

후처리

  1. customremoved
  2. washwashed 2× water
  3. dry with materialdried (MgSO4)
  4. customSolvent was removed

출처 및 근거

ORD 기록
ord-b5a4959aa8414c598e9a19d8cf9c0e80
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423053B2

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