Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiophosgene → 4-Methylsulfonylphenylisothiocyanate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiophosgene | HCID 10040 | — |
| 반응물 | 4-(Methylsulfonyl)aniline | HCID 79617 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Methylsulfonylphenylisothiocyanate | HCID 15078206 | 85.2% |
반응 단계
A solution of 4-methanesulfonylphenylamine (2.4 g, 14 mmol) was dissolved in a mixture of water (30 mL) and hydrochloric acid (9 mL, 37%). This was treated drop wise at room temperature with thiophosgene (1.5 g, 13.2 mmol) with good stirring. After 1 h, the suspension was filtered, washed with water and dried over P2O5 to give 2.4 g (85% yield) of 1-isothiocyanato4-methanesulfonylbenzene. 1H NMR (CDCl3), 300 MHz δ3.09 (s, 3H, CH3), 7.41(d, 2H, Aromatic), 7.98 (d, 2H, Aromatic).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423053B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-e092182de60b48639366dedfe02287ff |
| 출처 메모 | uspto-grants-2008_09 |