참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Phosphoric Acid | HCID 1004 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester | HCID 98424 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | 4-Cyano-tetrahydro thiophene-3-carboxylic acid methyl ester | HCID 68838098 | 75% |
반응 단계
To a solution of 4-oxotetrahydro thiophene-3-carboxylic acid methyl ester (4 g, 25 mmol) in methanol (7 ml), cooled at 0° C., a solution of potassium cyanide (1.68 g, 30 mmol) in water (10 ml) was added. The mixture was acidified with acetic acid (1.5 ml, 25 mmol) and stirred at 0° C. for 8 hours. Then the mixture was acidified with H3PO4 and diluted with brine (50 ml) and extracted with CH2Cl2 (4×30 ml). The organic layers were dried over sodium sulfate and concentrated to give 4-cyano-tetrahydro thiophene-3-carboxylic acid methyl ester in 75% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07423057B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-c127cb7733094ef09bbaf4730a2d36ae |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
