1-Benzyl-5-thiophen-3-yl-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid ethyl ester → 1-Benzyl-3-thiophen-3-yl-piperidine-4-carboxylic acid ethyl ester

HRID 30269노트

반응식

HRID 30269 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH2:7][CH2:8][N:9]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10][C:11]=1[C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)=[O:5])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4]([CH:6]1[CH2:7][CH2:8][N:9]([CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:10][CH:11]1[C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 1

HCID 597894381-Benzyl-5-thiophen-3-yl-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid ethyl ester

생성물 1

HCID 672067221-Benzyl-3-thiophen-3-yl-piperidine-4-carboxylic acid ethyl ester수율 71%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

A solution of the product from step b) (6.69 g, 20.4 mmol) was dissolved in EtOH (37 ml) and treated with 10% Pd/C (Wet Degussa type, 13.4 g) and heated to 40° C. for 2 days under H2 (1 atm). Next, the Pd/C was removed by filtration through celite, replaced with fresh 10% Pd/C (13.4 g) and the reaction was continued for two more days. The Pd/C was removed by filtration through celite and the EtOH was evaporated in vacuo to provide the subtitle compound (4.78 g, 71%). MS calculated for C19H23NO2S+H 330, observed 330.

후처리

  1. customNext, the Pd/C was removed by filtration through celite
  2. customThe Pd/C was removed by filtration through celite
  3. customthe EtOH was evaporated in vacuo

출처 및 근거

ORD 기록
ord-de03a7b6de03469b824e08f3fe77a04d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423056B2

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