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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 3028생성일: 2026년 10월 23일

Pyridine, hydrofluoride (1:1) → methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate

https://huagongshe.com/ko/reaction/3028

반응식

참여 물질

역할이름HCID투입량
반응물Pyridine, hydrofluoride (1:1)HCID 64774—
반응물methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoateHCID 22883798—
생성물methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoateHCID 2288379964%

반응 단계

Using as the material and reagent a hydrogen fluoride-pyridine solution (0.6 ml) and methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoate (466 mg), the same procedure as in Example 2 was performed to obtain methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate (192 mg, 64%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05731452
출처 데이터셋uspto-grants-1998_03
ORD IDord-e25048cd0b1a4d4a97c39af9be62f679
출처 메모uspto-grants-1998_03