Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromothiophene-2-carbaldehyde → 3-(4-Bromo-thiophen-2-yl)-acrylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| 반응물 | Nsc 634137 | HCID 184894 | — |
| 생성물 | 3-(4-Bromo-thiophen-2-yl)-acrylic acid methyl ester | HCID 54162519 | 78% |
반응 단계
4-Bromo-thiophene-2-carbaldehyde (44 g, 0.23 mol) and [Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic methyl ester (80.6 g, 0.253 mol) were treated by the method outlined in Example 34, step a) to afford the subtitle compound that was purified by column chromatography (SiO2) using a 0-60% ethylacetate-hexane gradient (46.22 g, yield: 78%). MS calculated for C8H7BrO2S+H: 247, observed: 247 249.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423056B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-f2db750a4b23425ba000baac5c129435 |
| 출처 메모 | uspto-grants-2008_09 |