Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine, hydrofluoride (1:1) → methyl(11R,13E,15S)-9-benzoyloxy-11,15-dihydroxy-7-thiaprosta-8,13-dienoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine, hydrofluoride (1:1) | HCID 64774 | — |
| 반응물 | methyl(11R,12S,13E,15S)-9-benzoyloxy-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienoate | HCID 22883804 | — |
| 생성물 | methyl(11R,13E,15S)-9-benzoyloxy-11,15-dihydroxy-7-thiaprosta-8,13-dienoate | HCID 22883805 | 88.3% |
반응 단계
Using as the material and reagent a hydrogen fluoride-pyridine solution (0.3 ml) and methyl(11R,12S,13E,15S)-9-benzoyloxy-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienoate (239 mg), the same procedure as in Example 2 was performed to obtain methyl(11R,13E,15S)-9-benzoyloxy-11,15-dihydroxy-7-thiaprosta-8,13-dienoate (144 mg, 86%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731452 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-a8c4e36b9c5748c2bdb42724db547b96 |
| 출처 메모 | uspto-grants-1998_03 |