4-benzyl-N-methoxy-N-methylmorpholine-2-carboxamide → 1-(4-Benzyl-morpholin-2 yl)-pentan-1-one

HRID 30324노트

반응식

HRID 30324 반응식
CON(C)[C:4]([CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:7]1)=[O:5].[CH2:20]([Mg]Br)[CH2:21][CH2:22][CH3:23]>O1CCCC1>[CH2:12]([N:8]1[CH2:9][CH2:10][O:11][CH:6]([C:4](=[O:5])[CH2:20][CH2:21][CH2:22][CH3:23])[CH2:7]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 597893084-benzyl-N-methoxy-N-methylmorpholine-2-carboxamideHCID 178418682HCID 178418682, 화합물2회

생성물 1

HCID 588548901-(4-Benzyl-morpholin-2 yl)-pentan-1-one수율 96%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Compound 82 is prepared from 2 (0.87 g, 3.28 mmol) in anhydrous tetrahydrofuran (30 mL) and commercially available (Aldrich) n-butyl magnesium bromide (2M solution in THF, 5 mmol, 2.5 mL, 1.5 eq) following General Procedure 1. After stirring for 1 hour further n-butyl magnesium bromide (2M solution in THF, 1.6 mmol, 0.8 mL) is added and stirring continued for 30 minutes. The reaction is quenched by addition of ammonium chloride solution (30 mL) followed by EtOAc. The organic phases are combined, dried over magnesium sulphate and the solvent is removed in vacuo to give 82 (0.82 g, 96%). MW 261.37; C16H23NO2; LCMS (6 minute method): m/z 262.4 [M+H]+, RT 2.34 mm.

후처리

  1. additionis added
  2. customThe reaction is quenched by addition of ammonium chloride solution (30 mL)
  3. dry with materialdried over magnesium sulphate
  4. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-7ed7a8891b1a4448a61d2d6a4bb7ad15
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423037B2

반응 노트

불러오는 중…