Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trichloroacetyl isocyanate → Methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trichloroacetyl isocyanate | HCID 76400 | — |
| 반응물 | Methyl 2-amino-3-thenoate | HCID 78381 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate | HCID 59789494 | — |
반응 단계
To a stirred solution of 2-amino-thiophene-3-carboxylic acid methyl ester (1 eq) in anhydrous THF (mL) was added trichloroacetyl isocyanate (1 eq) slowly over a period of 5 min. After the addition was complete, a precipitate formed and the reaction stirred for an additional 1 h. The desired product was obtained by filtration to give methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate (99%) as an off-white solid. The product was used in the next step without any further purification. LC/MS (ES, M+H=345).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423061B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-c9ad578238324991a9f7cd8df5c4dd1c |
| 출처 메모 | uspto-grants-2008_09 |