8-Cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester → 8-Cyclohexyl-2-{4-[1-(2-dimethylamino-acetyl)-piperidin-4-yl]-phenylamino}-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

반응식

[CH2:20]([CH3:21])[O:22][C:23](=[O:24])[c:25]1[c:26](=[O:45])[c:27]2[c:28]([n:29][c:30]([S:33]([CH3:34])(=[O:35])=[O:36])[n:31][cH:32]2)[n:37]([CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]2)[cH:38]1.[CH3:1][N:2]([CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([c:12]2[cH:13][cH:14][c:15]([NH2:18])[cH:16][cH:17]2)[CH2:10][CH2:11]1)[CH3:19]>>[CH3:1][N:2]([CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([c:12]2[cH:13][cH:14][c:15]([NH:18][c:30]3[n:29][c:28]4[c:27]([c:26](=[O:45])[c:25]([C:23]([O:22][CH2:20][CH3:21])=[O:24])[cH:38][n:37]4[CH:39]4[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]4)[cH:32][n:31]3)[cH:16][cH:17]2)[CH2:10][CH2:11]1)[CH3:19]