Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylacetone → 2-Amino-4-(5-chloro-2-pyridyl)-3-phenylbutane hydrochloride salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylacetone | HCID 7678 | — |
| 반응물 | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| 반응물 | 3-Acetonylpyridine | HCID 238414 | — |
| 반응물 | 5-Chloro-2-(chloromethyl)pyridine | HCID 14517151 | — |
| 생성물 | 2-Amino-4-(5-chloro-2-pyridyl)-3-phenylbutane hydrochloride salt | HCID 22270517 | — |
반응 단계
5-Chloro-2-choromethylpyridine (Weidmann, K. et al. J. Med. Chem. 1992, 35, 438) and phenylacetone were used in place of 4-chlorobenzyl bromide and 3-pyridylacetone in Step A of Reference Example 4. LC-MS: m/e 261 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423067B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-05e047b6489b44479102905253a5f15f |
| 출처 메모 | uspto-grants-2008_09 |