N-Methoxy-N-methylacetamide → 1-(3-Bromophenyl)propan-2-one

HRID 30356

반응식

HRID 30356 반응식
CON(C)[C:4](=[O:6])[CH3:5].[Br:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[CH2:12][Mg]Br>CCOCC>[Br:8][C:9]1[CH:10]=[C:11]([CH2:12][C:4]([CH3:5])=[O:6])[CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 537505N-Methoxy-N-methylacetamideHCID 178419662HCID 178419662, 화합물

생성물 1

HCID 27340931-(3-Bromophenyl)propan-2-one

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

To a solution of N-methoxy-N-methylacetamide (10 g, 0.10 mol) in 200 mL of ether at 0° C. was added 3-bromobenzylmagnesium bromide (0.25 M, 200 mL, 50 mmol). After stirring at 0° C. for 2 h, the reaction mixture was partitioned between hexane and saturated aqueous ammonium chloride. The organic layer was separated, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to dryness to give the title compound, which was used without further purification. 1H NMR (500 MHz, CD3OD): δ 7.5-7.1 (m, 4H), 3.78 (s, 2H), 2.19 (s, 3H).

후처리

  1. customthe reaction mixture was partitioned between hexane and saturated aqueous ammonium chloride
  2. customThe organic layer was separated
  3. washwashed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-fc7cef611e73475ab104272aeb826061
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423067B2

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