Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 304생성일: 2026년 10월 23일
3-(Trifluoromethyl)benzylamine → 6-[[3-(Trifluoromethyl)phenyl]methylamino]pyridine-3-carboxamide
https://huagongshe.com/ko/reaction/304
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(Trifluoromethyl)benzylamine | HCID 75962 | — |
| 반응물 | 6-Chloronicotinamide | HCID 80456 | — |
| 시약 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 6-[[3-(Trifluoromethyl)phenyl]methylamino]pyridine-3-carboxamide | HCID 78915653 | 0% |
반응 단계
To a stirred solution of 6-chloronicotinamide (0.053 g, 0.34 mmol), sodium 2-methylpropan-2-olate (0.065 g, 0.68 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.020 g, 0.03 mmol) and diacetoxypalladium (7.60 mg, 0.03 mmol) in DME (1 mL) was added (3-(trifluoromethyl)phenyl)methanamine (0.049 mL, 0.34 mmol). The reaction was run in microwave at 120 C for 4h. only traces of product observed. Reaction wasted.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-058876800e774f05bf1b52bd00238231 |
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| 출처 메모 | 750 AstraZeneca ELN dataset |
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