Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Malonate → HCID 178418389, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Acetamidine monohydrochloride | HCID 67170 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 4,6-Dihydroxy-2-methylpyrimidinamine | HCID 178418345 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178418389 | HCID 178418389 | — |
반응 단계
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05732717 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-4d14267579d347aaab5da8765031fa8d |
| 출처 메모 | uspto-grants-1998_03 |