Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N,N',N',N'',N''-Hexamethylmethanetriamine → (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N,N',N',N'',N''-Hexamethylmethanetriamine | HCID 79831 | — |
| 반응물 | 2-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester | HCID 11088396 | — |
| 반응물 | (S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11687992 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11523197 | — |
반응 단계
According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423152B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-bbd7d798654d40d2a16d1a5d7de0ddf3 |
| 출처 메모 | uspto-grants-2008_09 |