Bromomethyl 4-methoxyphenyl ketone → 5-Amino-2-(1-[4-methoxyphenylcarbonylmethyl]benzimidazol-2-yl)-pyrazole

HRID 30506

반응식

HRID 30506 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][N:5]([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[N:6]=1.[CH3:16][O:17][C:18]1[CH:27]=[CH:26][C:21]([C:22](=[O:25])[CH2:23]Br)=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>O>[NH2:1][C:2]1[CH:3]=[CH:4][N:5]([C:7]2[N:11]([CH2:23][C:22]([C:21]3[CH:26]=[CH:27][C:18]([O:17][CH3:16])=[CH:19][CH:20]=3)=[O:25])[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[N:6]=1

참가 물질

5

반응물 3

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 11430Potassium CarbonateHCID 574644725-amino-2-(1H-benzimidazol-2-yl)pyrazole

생성물 1

HCID 574943345-Amino-2-(1-[4-methoxyphenylcarbonylmethyl]benzimidazol-2-yl)-pyrazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of 5-amino-2-(1H-benzimidazol-2-yl)pyrazole (0.10 g, 0.5 mmol), p-methoxyphenacyl bromide (0.204 g, 0.9 mmol) and dry potassium carbonate (0.173 g, 1.25 mmol) is stirred at room temperature for 16 hours. The mixture is diluted with water and the product extracted with ethyl acetate. The product is purified by chromatography on silicagel. M.p. 136-140° C., 1H-NMR (400 MHz, d6-DMSO): 8.04 (d, 2H); 7.58 (m, 2H); 7.28 (m, 3H); 7.11 (d, 2H); 6.84 (s, 2H); 6.26 (s, 2H); 5.39 (d, 1H); 3.87 (s, 3H).

후처리

  1. extractionthe product extracted with ethyl acetate
  2. customThe product is purified by chromatography on silicagel

출처 및 근거

ORD 기록
ord-f8b0f03890c64aedba67ef2fd6510344
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423157B2

연결된 노트

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