Tetrahydrofuran → 5-(5-Bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepane-3-thione

반응식

[Br:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH3:18])[NH:9][C:10](=[O:17])[CH2:11][O:12][CH2:13][C:14]2([F:15])[F:16])[cH:7]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([P:26]2(=[S:29])[S:27][P:28]([c:30]3[cH:31][cH:32][c:33]([O:34][CH3:35])[cH:36][cH:37]3)(=[S:38])[S:39]2)[cH:40][cH:41]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6]([C:8]2([CH3:18])[NH:9][C:10](=[S:29])[CH2:11][O:12][CH2:13][C:14]2([F:15])[F:16])[cH:7]1

참가 물질

반응물 3

HCID 8028Tetrahydrofuran

HCID 87949Lawesson's reagent

HCID 666660575-(5-Bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-one

생성물 1

HCID 866502735-(5-Bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepane-3-thione

출처 및 근거

ORD 기록: ord-8d472f0f366a465eae55002a9d948c05
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

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