Tetrahydrofuran → 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]propionic acid

HRID 30635노트

반응식

HRID 30635 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[CH:10][C:9]=2/[CH:14]=[CH:15]/[C:16]([OH:18])=[O:17])=[CH:4][CH:3]=1.O1CCCC1.[H][H]>[C].[Pd].C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([CH3:13])[N:11]=[CH:10][C:9]=2[CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 8028TetrahydrofuranHCID 69208981(2E)-3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]acrylic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 692099283-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]propionic acid수율 97%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A mixture of (2E)-3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]acrylic acid (0.80 g), 5% palladium-carbon (0.30 g), tetrahydrofuran (10 ml) and ethanol (10 ml) was stirred at room temperature for 6 hrs. in a hydrogen atmosphere at atmospheric pressure. Palladium-carbon was filtered off and the filtrate was concentrated to give 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]propionic acid (0.78 g, yield 97%) as a colorless solid.

후처리

  1. filtrationPalladium-carbon was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-dd014909edac47f18110df883cab990e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423159B2

반응 노트

불러오는 중…