Dimethylformamide → 5-methyl-1-(4-nitrobenzyl)-1H-imidazole

HRID 30694

반응식

HRID 30694 반응식
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[N+:7]([C:10]1[CH:17]=[CH:16][C:13]([CH2:14]Br)=[CH:12][CH:11]=1)([O-:9])=[O:8].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[CH3:1][C:2]1[N:3]([CH2:14][C:13]2[CH:16]=[CH:17][C:10]([N+:7]([O-:9])=[O:8])=[CH:11][CH:12]=2)[CH:4]=[N:5][CH:6]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 660114-Nitrobenzyl bromideHCID 178418800HCID 178418800, 화합물

생성물 1

HCID 4266335-methyl-1-(4-nitrobenzyl)-1H-imidazole수율 3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4-methyl-1H-imidazole (25.5 g), 4-nitrobenzyl bromide (56 g), potassium carbonate (86 g) and N,N-dimethylformamide (500 ml) was stirred at room temperature for 14 hrs. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to give 5-methyl-1-(4-nitrobenzyl)-1H-imidazole (1.6 g, 3%) as crystals from a fraction eluted with methanol-ethyl acetate (1:20, v/v). Recrystallization thereof from ethyl acetate-isopropyl ether gave colorless prism crystals. melting point: 120-121° C.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0b7b3efceb2e420bba2ba80e31ff815e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423159B2

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