(4-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methanol → HCID 85969110, 화합물

HRID 30706노트

반응식

HRID 30706 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][N:11]([CH3:15])[C:12]=2[CH2:13][OH:14])=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][N:11]([CH3:15])[C:12]=2[CH:13]=[O:14])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 69207780(4-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methanol

생성물 1

HCID 85969110HCID 85969110, 화합물수율 70%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of [4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]methanol (250 mg), activated manganese dioxide (1.0 g) and tetrahydrofuran (10 ml) was stirred at room temperature for 3 hrs. The reaction mixture was filtered, and the organic layer was concentrated to give 4-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carbaldehyde (172 mg, yield 70%) as pale-yellow crystals.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe organic layer was concentrated

출처 및 근거

ORD 기록
ord-1e93fb7e727246f5890a765717768e33
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423159B2

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