Benzyl [2-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate → [2-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetic acid

HRID 30750노트

반응식

HRID 30750 반응식
[CH:1]([C:4]1[CH:21]=[C:20]([B:22]2[O:26][C:25]([CH3:28])([CH3:27])[C:24]([CH3:30])([CH3:29])[O:23]2)[CH:19]=[CH:18][C:5]=1[O:6][CH2:7][C:8]([O:10]CC1C=CC=CC=1)=[O:9])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[CH:1]([C:4]1[CH:21]=[C:20]([B:22]2[O:26][C:25]([CH3:28])([CH3:27])[C:24]([CH3:30])([CH3:29])[O:23]2)[CH:19]=[CH:18][C:5]=1[O:6][CH2:7][C:8]([OH:10])=[O:9])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 86605504Benzyl [2-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate

생성물 1

HCID 23134282[2-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetic acid수율 83.3%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A mixture of benzyl [2-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate (0.24 g) and 10% palladium-carbon (0.05 g) in ethanol (10 mL) was stirred at room temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure to afford the title compound (0.156 g).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a501d2f600a24a658735bf595c705db3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423185B2

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