Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-2-fluoroaniline → N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-2-fluoroaniline | HCID 123050 | — |
| 반응물 | 2-Chloro-6-fluorobenzothiazole | HCID 2049870 | — |
| 반응물 | N-(4-bromo-2-fluorophenyl)-N-(6-trifluoromethoxy-1,3-benzothiazol-2-yl)amine | HCID 21985778 | — |
| 반응물 | N-(4-bromo-2-fluorophenyl)-4-methyl-1,3-benzothiazol-2-amine | HCID 23549342 | — |
| 생성물 | N-(4-bromo-2-fluorophenyl)-6-fluoro-1,3-benzothiazol-2-amine | HCID 7147089 | 78% |
반응 단계
In a similar manner to that described above for the preparation of N-(4-bromo-2-fluorophenyl)-4-methyl-1,3-benzothiazol-2-amine and N-(4-bromo-2-fluorophenyl)-N-(6-trifluoromethoxy-1,3-benzothiazol-2-yl)amine, using 2-chloro-6-fluoro-1,3-benzothiazole and 2-fluoro-4-bromoaniline, was prepared the desired product as a white solid (78% yield). 1H NMR (400 MHz, DMSO-d6) δ 10.50 (s, 1H), 8.60 (t, 1H), 7.80 (d, 1H), 7.60 (m, 2H), 7.40 (d, 1H), 7.20 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423156B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-fb12bb7feef047119a0c927a4f97ec34 |
| 출처 메모 | uspto-grants-2008_09 |