Putrescine → 3-((4-Aminobutyl)amino)propanenitrile

HRID 3091

반응식

HRID 3091 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6].[C:7](#[N:10])[CH:8]=[CH2:9]>CO>[C:7]([CH2:8][CH2:9][NH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH2:6])#[N:10]

참가 물질

4

반응물 2

HCID 1045PutrescineHCID 7855Acrylonitrile

생성물 1

HCID 125483743-((4-Aminobutyl)amino)propanenitrile수율 80%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 1,4-diaminobutane (4.3 g, 48.8 mmole) in methanol (1.5 ml) was added a solution of acrylonitrile (3.1 g, 58.4 mmole) in methanol (1.5 ml) at 0° C., and the mixture was stirred for twelve hours. Evaporation of the solvent in vacuo afforded N-(2'-cyanoethyl)-1,4-diaminobutane as a colorless oil (5.5 g, 80% yield). 1H NMR (400 MHz, CDCl3) δ: 1.45 (4H, br, --CH2 CH2 --), 2.46 (2H, t), 2.58 (2H, t), 2.62 (2H, t), 2.84 (2H, t).

후처리

  1. customEvaporation of the solvent in vacuo

출처 및 근거

ORD 기록
ord-a9146312177a4f9b96171064a8052dc6
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733899

연결된 노트

불러오는 중…