5-bromo-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide → 5-[7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridine-3-sulfonic acid (2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-amide

반응식

[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[CH:13])[F:24].[OH:25][CH2:26][C:27]([CH3:28])([CH2:29][OH:30])[NH:31][S:32](=[O:33])(=[O:34])[c:35]1[cH:36][n:37][cH:38][c:39]([Br:41])[cH:40]1>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[C:13][c:39]1[cH:38][n:37][cH:36][c:35]([S:32]([NH:31][C:27]([CH2:26][OH:25])([CH3:28])[CH2:29][OH:30])(=[O:33])=[O:34])[cH:40]1)[F:24]