Monoethyl malonate → N-[(S)-5-(2-Methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-malonamic acid ethyl ester

HRID 31018

반응식

HRID 31018 반응식
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[CH2:22]([O:24][C:25](=[O:30])[CH2:26][C:27](O)=[O:28])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:30])[CH2:26][C:27]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2)=[O:28])[CH3:23]

참가 물질

3

반응물 2

HCID 70615Monoethyl malonateHCID 58972510(S)-7-Amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one

생성물 1

HCID 58972509N-[(S)-5-(2-Methoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-malonamic acid ethyl ester

실험 절차

Using (S)-7-Amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and malonic acid monoethyl ester, the title compound was prepared in the same manner as described for example 1c. Colorless, viscous oil (>98%). MS: m/e=397(M+H+).

출처 및 근거

ORD 기록
ord-928d68467bfe462692c2155fa724ebcd
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425551B2

연결된 노트

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