2-chloro-N4-(2,6-dimethoxypyridin-3-yl)-5-fluoro-4-pyrimidineamine → N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-N4-(2,6-dimethoxypyridin-3-yl)-5-fluoro-2,4-pyrimidinediamine

반응식

[Cl:15][c:16]1[n:17][cH:18][c:19]([F:33])[c:20]([NH:22][c:23]2[c:24]([O:31][CH3:32])[n:25][c:26]([O:29][CH3:30])[cH:27][cH:28]2)[n:21]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:14]1)[CH2:7][CH:8]([C:10](=[O:11])[O:12][CH3:13])[O:9]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:14]1)[CH2:7][CH:8]([C:10](=[O:11])[O:12][CH3:13])[O:9]2)[c:16]1[n:17][cH:18][c:19]([F:33])[c:20]([NH:22][c:23]2[c:24]([O:31][CH3:32])[n:25][c:26]([O:29][CH3:30])[cH:27][cH:28]2)[n:21]1

참가 물질

반응물 2

HCID 220606582-chloro-N4-(2,6-dimethoxypyridin-3-yl)-5-fluoro-4-pyrimidineamine

HCID 22060823Methyl 5-amino-2,3-dihydrobenzofuran-2-carboxylate

생성물 1

HCID 22060286N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-N4-(2,6-dimethoxypyridin-3-yl)-5-fluoro-2,4-pyrimidinediamine

출처 및 근거

ORD 기록: ord-90466696153f4a9ebe501d358a04a1d4
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

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