Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanamine, 2,2,2-trifluoro- → (S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(2,2,2-trifluoro-ethyl)-malonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| 반응물 | (R)-N-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid | HCID 58972476 | — |
| 생성물 | (S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(2,2,2-trifluoro-ethyl)-malonamide | HCID 58972465 | 58% |
반응 단계
Using (R)—N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid and 2,2,2-trifluoro-ethylamine, the title compound was prepared in the same manner as described for example 1c. Final chromatography on silica (heptane/ethyl acetate gradient from 5 to 100%) afforded the title compound as white solid (58%). MS: m/e=558(M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425551B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-60c6205f6fe749a0a251eee904ad5c40 |
| 출처 메모 | uspto-grants-2008_09 |