Ethanamine, 2,2,2-trifluoro- → (S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(2,2,2-trifluoro-ethyl)-malonamide

HRID 31035

반응식

HRID 31035 반응식
[CH2:1]([O:8][CH2:9][CH2:10][N:11]1[C:17](=[O:18])[C@@H:16]([NH:19][C:20](=[O:27])[C@:21]([F:26])([CH3:25])[C:22](O)=[O:23])[C:15]2[CH:28]=[CH:29][CH:30]=[CH:31][C:14]=2[C:13]2[CH:32]=[CH:33][CH:34]=[CH:35][C:12]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:36][C:37]([F:41])([F:40])[CH2:38][NH2:39]>>[CH2:1]([O:8][CH2:9][CH2:10][N:11]1[C:17](=[O:18])[C@@H:16]([NH:19][C:20](=[O:27])[C@:21]([F:26])([CH3:25])[C:22]([NH:39][CH2:38][C:37]([F:41])([F:40])[F:36])=[O:23])[C:15]2[CH:28]=[CH:29][CH:30]=[CH:31][C:14]=2[C:13]2[CH:32]=[CH:33][CH:34]=[CH:35][C:12]1=2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 58972476(R)-N-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid

생성물 1

HCID 58972465(S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(2,2,2-trifluoro-ethyl)-malonamide수율 58%

실험 절차

Using (R)—N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid and 2,2,2-trifluoro-ethylamine, the title compound was prepared in the same manner as described for example 1c. Final chromatography on silica (heptane/ethyl acetate gradient from 5 to 100%) afforded the title compound as white solid (58%). MS: m/e=558(M+H+).

후처리

  1. customthe title compound was prepared in the same manner

출처 및 근거

ORD 기록
ord-60c6205f6fe749a0a251eee904ad5c40
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425551B2

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