1-(2-Bromoethoxy)-4-fluorobenzene → [(S)-5-[2-(4-fluoro-phenoxy)-ethyl]-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-carbamic acid tert-butyl ester

HRID 31046노트

반응식

HRID 31046 반응식
[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)([CH3:4])([CH3:3])[CH3:2].[F:25][C:26]1[CH:35]=[CH:34][C:29]([O:30][CH2:31][CH2:32]Br)=[CH:28][CH:27]=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:32][CH2:31][O:30][C:29]2[CH:34]=[CH:35][C:26]([F:25])=[CH:27][CH:28]=2)[C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 20641711-(2-Bromoethoxy)-4-fluorobenzeneHCID 58972520((S)-6-Oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 58972539[(S)-5-[2-(4-fluoro-phenoxy)-ethyl]-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-carbamic acid tert-butyl ester

실험 절차

Using ((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-carbamic acid tert-butyl ester and 4-fluorophenoxy-ethylbromide, the title product was prepared in the same manner as described for example 1a (84%). White solid. MS: m/e=463(M+H+).

출처 및 근거

ORD 기록
ord-0af6b94a72a14b4ea3fbb0a97a40efd0
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425551B2

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