2-(2-Bromoethoxy)propane → [(S)-5-(2-Isopropoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-carbamic acid tert-butyl ester

HRID 31047노트

반응식

HRID 31047 반응식
[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)([CH3:4])([CH3:3])[CH3:2].Br[CH2:26][CH2:27][O:28][CH:29]([CH3:31])[CH3:30]>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:26][CH2:27][O:28][CH:29]([CH3:31])[CH3:30])[C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C:10]2[CH:20]=[CH:21][CH:22]=[CH:23][C:9]1=2)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 38308232-(2-Bromoethoxy)propaneHCID 58972520((S)-6-Oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 58972515[(S)-5-(2-Isopropoxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-carbamic acid tert-butyl ester

실험 절차

Using ((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-carbamic acid tert-butyl ester and 2-(2-bromo-ethoxy)-propane, the title product was prepared in the same manner as described for example 1a (69%). Pink, viscous oil. MS: m/e=411(M+H+).

출처 및 근거

ORD 기록
ord-2b0494fb4d6346ce85d7a024923899d3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425551B2

반응 노트

불러오는 중…