Water → HCID 86601048, 화합물

HRID 31053노트

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HRID 31053 반응식
[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[CH:3]=1.[N:14]([O-])=[O:15].[Na+].O>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6](=[S:12])[NH:5][C:4](=[O:13])[C:3]=1[N:14]=[O:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 866010496-Amino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

생성물 1

HCID 86601048HCID 86601048, 화합물수율 96.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
75 °C

실험 절차

6-Amino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.0 g, 5.0 mmol) was suspended in 10% acetic acid (20 mL). Sodium nitrite (0.38 g, 5.5 mmol) was added and the resulting mixture was heated at 75° C. for 1 h. The reaction mixture became first pink and then purple. The purple mixture was cooled to room temperature. Then water (20 mL) was added and the purple solid was collected by filtration and washed with water to give the title compound (1.1 g, 92% yield). This solid was used in the following step without further purification.

후처리

  1. temperatureThe purple mixture was cooled to room temperature
  2. filtrationthe purple solid was collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-5d11d0c8f3e44bd3b01e763a565a9d7f
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425560B2

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