Formic Acid → 3-Isobutyl-2-thioxanthine

HRID 31054노트

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HRID 31054 반응식
[NH2:1][C:2]1[C:3](=[O:14])[NH:4][C:5](=[S:13])[N:6]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7]=1[NH2:8].[CH:15](O)=O>>[CH2:9]([N:6]1[C:7]2[N:8]=[CH:15][NH:1][C:2]=2[C:3](=[O:14])[NH:4][C:5]1=[S:13])[CH:10]([CH3:11])[CH3:12]

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 866010505,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

생성물 1

HCID 103312193-Isobutyl-2-thioxanthine

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온도
100 °C

실험 절차

5,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.22 g, 1.0 mmol) was suspended in formic acid (1.5 mL) and this solution was heated at 100° C. for 1 h. Excess formic acid was evaporated off under reduced pressure. 10% Sodium hydroxide (1.5 mL) was added to the orange solid and the resulting solution was heated at 100° C. for 15 minutes. Water was added and the pH of the solution adjusted to pH 4 with dilute acetic acid. The resulting slurry was stirred for 0.5 h at ambient temperature, then the precipitate was collected by filtration and washed with water. Yield: (0.21 g, 90%).

후처리

  1. customExcess formic acid was evaporated off under reduced pressure
  2. addition10% Sodium hydroxide (1.5 mL) was added to the orange solid
  3. temperaturethe resulting solution was heated at 100° C. for 15 minutes
  4. additionWater was added
  5. filtrationthe precipitate was collected by filtration
  6. washwashed with water

출처 및 근거

ORD 기록
ord-7b4af4c03db64f289d297e61e4f4e038
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425560B2

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