Triethylorthoaceate → 3-Isobutyl-8-methyl-2-thioxanthine

반응식

[NH2:1][C:2]1[C:3](=[O:14])[NH:4][C:5](=[S:13])[N:6]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7]=1[NH2:8].[CH2:15](C(CC)(CC)C([O-])([O-])[O-])[CH3:16]>>[CH2:9]([N:6]1[C:7]2[N:8]=[C:15]([CH3:16])[NH:1][C:2]=2[C:3](=[O:14])[NH:4][C:5]1=[S:13])[CH:10]([CH3:11])[CH3:12]

참가 물질

반응물 2

HCID 21875354Triethylorthoaceate

HCID 866010505,6-Diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

생성물 1

HCID 103993113-Isobutyl-8-methyl-2-thioxanthine수율 95%

반응 조건

온도: 130 °C

실험 절차

A mixture of 5,6-diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (Example 6 (c), 0.70 g, 3.26 mmol) and triethylorthoacetate (10 mL) was heated at 130° C. for 2 h and 40 minutes. Then the reaction mixture was cooled on an ice-bath, the solid filtered off and washed with ethanol (4×2 mL). The solid was dried in vacuo yielding the title compound (0.71 g, 95%).

후처리

temperatureThen the reaction mixture was cooled on an ice-bath
filtrationthe solid filtered off
washwashed with ethanol (4×2 mL)
customThe solid was dried in vacuo

출처 및 근거

ORD 기록: ord-f521a926c71542608a44aad284863ad0
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07425560B2

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