Methylamine → 1-Isobutyl-3-methylthiourea

HRID 31064

반응식

HRID 31064 반응식
[CH3:1][NH2:2].[CH2:3]([N:7]=[C:8]=[S:9])[CH:4]([CH3:6])[CH3:5]>>[CH2:3]([NH:7][C:8]([NH:2][CH3:1])=[S:9])[CH:4]([CH3:6])[CH3:5]

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 68960Isobutyl isothiocyanate

생성물 1

HCID 155682431-Isobutyl-3-methylthiourea수율 98.2%

실험 절차

Methylamine (2M in methanol, 20.0 mL, 40.2 mmol) was added dropwise to isobutylisothiocyanate (2.00 mL, 16.5 mmol) during 15 minutes at room temperature. The reaction mixture was heated to reflux for 3.5 h and the solvent was evaporated off to give the title compound (2.37 g, 98%) as a colourless oil.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 3.5 h
  3. customthe solvent was evaporated off

출처 및 근거

ORD 기록
ord-daba692c6a114204a87d5a67bd05525c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425560B2

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