Sulfuric Acid → 4,6-dimethyl-1H-indole-2,3-dione

HRID 3108

반응식

HRID 3108 반응식
[OH:1]S(O)(=O)=O.[CH3:6][C:7]1[CH:8]=[C:9]([NH:14][C:15](=[O:19])[CH:16]=NO)[CH:10]=[C:11]([CH3:13])[CH:12]=1>O>[CH3:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]2[C:8]=1[C:16](=[O:1])[C:15](=[O:19])[NH:14]2

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 53405864N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide

생성물 1

HCID 23861614,6-dimethyl-1H-indole-2,3-dione수율 72.6%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

To a stirred warm (60°-70° C.) solution of concentrated H2SO4 (60 mL) and water (6 mL) was added in small portions N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide (15.0 g, 78 mM) so that the temperature of the reaction mixture did not exceed 70° C. After the addition was completed, the reaction mixture was heated at 80° C. for 10 min and then cooled and poured onto ice. The resulting mixture was filtered and the collected solids were washed with water and dried to provide the title compound (9.93 g, 72.6%); MS(CI): 176.

후처리

  1. customdid not exceed 70° C
  2. additionAfter the addition
  3. temperaturecooled
  4. additionpoured onto ice
  5. filtrationThe resulting mixture was filtered
  6. washthe collected solids were washed with water
  7. customdried

출처 및 근거

ORD 기록
ord-d8484403e58847a9996f4809780dd83c
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733910

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