Acetic Acid → 4-Methoxy-2-nitrobenzoic acid

HRID 3111

반응식

HRID 3111 반응식
[N+:1]([C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8]C=1C#N)([O-:3])=[O:2].[C:14]([OH:17])(=[O:16])[CH3:15].S(=O)(=O)(O)O>O>[N+:1]([C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:15]=1[C:14]([OH:17])=[O:16])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 2886654-Methoxy-2-nitrobenzonitrile

생성물 1

HCID 2886574-Methoxy-2-nitrobenzoic acid수율 91.8%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 2-nitro-4-methoxybenzonitrile (14.0 g, 78.6 mM) in a solution of acetic acid (28 mL), sulfuric acid (28 mL) and water (28 mL) was refluxed for 11 hr, allowed to cool and diluted with water (200 mL). The resulting precipitate which formed was collected, washed with water and dried to give the title benzoic acid (14.2 g, 91.8%) as a yellow crystalline solid; MS(CI): 198 (M+H).

후처리

  1. temperaturewas refluxed for 11 hr
  2. temperatureto cool
  3. customThe resulting precipitate which formed
  4. customwas collected
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-25ba7dfa0f824982b8c2a5e57de886c1
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733910

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