3-Fluorophenylacetic acid → 2-(3-Fluorophenyl)indan-5-ol

HRID 31244

반응식

HRID 31244 반응식
[C:1]1([CH:7]2[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([OH:16])[CH:13]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:17]C1C=C(CC(O)=O)C=CC=1>>[F:17][C:3]1[CH:2]=[C:1]([CH:7]2[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([OH:16])[CH:13]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 676173-Fluorophenylacetic acidHCID 179784482-Phenylindan-5-ol

생성물 1

HCID 179785082-(3-Fluorophenyl)indan-5-ol

실험 절차

2-(3-Fluorophenyl)indan-5-ol was prepared as described for 2-phenylindan-5-ol in Example 25(a-e) using 5 g of 3-fluorophenylacetic acid. 1H-NMR (400 MHz, d6-DMSO): 9.09 (s, 1H), 7.37-7.29 (m, 1H), 7.14-7.7.09 (m, 2H), 7.02-6.98 (m, 2H), 6.64 (d, 1H, J 1.7 Hz), 6.55 (dd, 1H, J 2.3, 8.1 Hz), 3.63 (k, 1H, J 8.3 Hz), 3.24-3.12 (m, 2H), 2.94-2.79 (m, 2H).

출처 및 근거

ORD 기록
ord-ad77a607e21b46009db757a8370ec371
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425568B2

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