Water → 4-Chloro-5-methyl-1H-indole-2,3-dione

HRID 31357노트

반응식

HRID 31357 반응식
[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4](SC)[C:5](=[O:12])[NH:6]2.ClN1C(=[O:21])CCC1=O.C1COCC1.O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:21])[C:5](=[O:12])[NH:6]2

참가 물질

6

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 31398ChlorosuccinimideHCID 219059304-Chloro-5-methyl-3-(methylthio)indolin-2-one

생성물 1

HCID 225608594-Chloro-5-methyl-1H-indole-2,3-dione수율 80.9%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

This compound is prepared according to the procedure described in step B of Preparation 1.23, starting with 0.72 g of 4-chloro-5-methyl-3-methylthio-1,3-dihydro-2H-indol-2-one and 0.422 g of N-chlorosuccinimide in 72 ml of carbon tetrachloride, and then 58 ml of THF and 14 ml of water. The product obtained is chromatographed on silica gel, eluting with DCM and then with a gradient of a DCM/EtOAc mixture up to (90/10; v/v). 0.5 g of the expected product is obtained.

후처리

  1. customThis compound is prepared
  2. customdescribed in step B of Preparation 1.23
  3. customThe product obtained
  4. customis chromatographed on silica gel
  5. washeluting with DCM

출처 및 근거

ORD 기록
ord-a3e00b97b8384adb9e456ce4da6926c6
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425566B2

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