참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Levofloxacin | HCID 149096 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | Levofloxacin Hydrate | HCID 3033924 | 84% |
반응 단계
1.5 g of levofloxacin crude was put in suspension in 15 ml of MEK. The mixture was heated to reflux temperature until complete dissolution of the material. Then the solution was cooled to −5° C. over a period of 3 hours. The precipitate was filtrated under vacuum, washed with 1.5 ml of MEK and dried at 30° C. in a vacuum oven to give 840 mg (84%) of purified levofloxacin hemihydrate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07425628B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-5ef30b4014b14c6b9ef8a9cf7daa197a |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
