Dimethylamine → [5-(4-Iodophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-dimethylamine

HRID 31407

반응식

HRID 31407 반응식
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=2)=[N:6][N:7]=1.[I-].[K+].[CH3:17][NH:18][CH3:19]>O1CCCC1>[I:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:4][C:3]([CH2:2][N:18]([CH3:19])[CH3:17])=[N:7][N:6]=2)=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 4875Potassium IodideHCID 70910682-(Chloromethyl)-5-(4-iodophenyl)-1,3,4-oxadiazole2회

생성물 1

HCID 69314787[5-(4-Iodophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-dimethylamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
20 °C

실험 절차

2-Chloromethyl-5-(4-iodophenyl)-[1,3,4]oxadiazole (Intermediate 7) (48 mg, 0.15 mmol) and potassium iodide (25 mg, 0.15 mmol) were dissolved in 2M dimethylamine in tetrahydrofuran (2 ml) and stirred for 18 hours at 20° C. The reaction was evaporated to dryness in vacuo and the product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol).

후처리

  1. customThe reaction was evaporated to dryness in vacuo
  2. customthe product was purified on a 10 g silica SPE cartridge (stepped solvent gradient 80:20 ethyl acetate:cyclohexane, 100% ethyl acetate, 95:5 ethyl acetate:methanol)

출처 및 근거

ORD 기록
ord-c2559fa983e245c3a7bffa15abcab064
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425555B2

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