4Iodo-benzoic acid N'-(2,2-dimethyl-propionyl)-hydrazide → 4-Iodobenzenecarbohydrazide
반응식
CC(C)(C)C([NH:5][NH:6][C:7](=[O:15])[C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][CH:9]=1)=O>FC(F)(F)C(O)=O>[I:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][NH2:5])=[O:15])=[CH:9][CH:10]=1참가 물질
3
실험 절차
Trifluoroacetic acid (10 ml) was added to 4iodo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide (Intermediate 13) (1 g, 2.76 mmol) and stirred at room temperature for 2 hours. The trifluoroactic acid was removed in vacuo and the residue partitioned between ethyl acetate (50 ml) and saturated aqueous sodium bicarbonate solution (50 ml). The organic layer was washed with water (50 ml), brine (50 ml), dried over magnesium sulfate, filtered and the solvent removed in vacuo. The desired product was obtained as a white solid (0.55 g, 2.1 mmol).
후처리
- customThe trifluoroactic acid was removed in vacuo
- customthe residue partitioned between ethyl acetate (50 ml) and saturated aqueous sodium bicarbonate solution (50 ml)
- washThe organic layer was washed with water (50 ml), brine (50 ml)
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customthe solvent removed in vacuo
출처 및 근거
- ORD 기록
- ord-ac02ab09da504815b72b4796a3df3564
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07425555B2
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