Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl orthopropionate → N-cyclopropyl-4'-(5-ethyl-1,3,4-oxadiazol-2-yl)-6-methyl-1,1'-biphenyl-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl orthopropionate | HCID 66995 | — |
| 반응물 | N-cyclopropyl-4'-(hydrazinocarbonyl)-6-methyl-1,1'-biphenyl-3-carboxamide | HCID 11438287 | — |
| 생성물 | N-cyclopropyl-4'-(5-ethyl-1,3,4-oxadiazol-2-yl)-6-methyl-1,1'-biphenyl-3-carboxamide | HCID 11725251 | — |
반응 단계
N-Cyclopropyl-4′-(hydrazinocarbonyl)-6-methyl-1,1′-biphenyl-3-carboxamide (Intermediate 40) (50 mg) in triethylorthopropionate (5 ml) was heated at 150° C. for 18 hours. The excess triethylorthopropionate was evaporated under vacuum and the residue purified by bond-elut (silica), eluting with an ethyl acetate/cyclohexane gradient. The solvent was evaporated from the product fractions under vacuum to give N-cyclopropyl-4′-(5-ethyl-1,3,4-oxadiazol-2-yl)-6-methyl-1,1′-biphenyl-3-carboxamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425555B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-13e7cc1702f94e2989b1e4c1c9965463 |
| 출처 메모 | uspto-grants-2008_09 |